Authors : Tayefi Nasrabadi Hamid, Naghikhani Mehrdad, Soleimanirad Jafar, Joghataei Mohammad Taghi, Arablu Amir Massoud, Yaghmaee Ramin
Introduction: Myofascial Trigger Points (MTrPs) are one of the common causes of musculoskeletal pain. Many of people are suffer pain of this syndrome. This syndrome is a complex process that involves the interaction of biochemical factors, histological change, nociceptors and the neurons of both the central and peripheral nervous systems. Recent studies of MTrPs have focused on the role of biochemical markers such as neuropeptides and inflammatory mediators, etc. Our main aim in the present article was to review studies regarding the biochemical and histological changes related to myofascial pain.
Method: A comprehensive search was performed of databases Science Direct, Google Scholar and PubMed using OR AND between the selected keywords: myofascial pain, MTrP, prostaglandins, calcitonin gene related peptide, tumor necrosis factor, inflammation mediators and microdialysis in articles published between 1996 to 2016.
Result: Eighty-five articles were initially obtained from the search of the electronic sources. Sixteen articles were selected after reading and classifying materials and articles based on the inclusion criteria.
Conclusion: The process of inflammation and its involvement in muscle pain and cytokines secreted by inflammatory cells and muscle tissue leads to increased inflammation and pain. Interaction among mediators, muscle tissue and neurons of the spinal cord lead to persistent pain and change pain type. This pathophysiologic process in trigger points may suggest useful and effective ways of providing better treatment for people experiencing myofascial pain.
Keywords: Trigger Point; Muscle Pain; Biochemical Marker; Inflammatory Mediator; Microdialysis; MTrP.